Comparative analysis of changes in proliferative-apoptotic and hormonal status of non-invasive papillary urothelial carcinomas with molecular subtypes of invasive carcinomas

Invasive urothelial carcinoma is the most common bladder malignancy, comprising 90% of all primary carcinomas. According to statistics Georgia, according NCDC data, cancer third among men. As a result non-invasive carcinoma, 70% operated patients developed recurrence in 5-year period after surgical intervention on urinary bladder, which share advanced, metastatic cases 10-20%.Therefore, regardless same degree differentiation and staging, progression varies different patients. A cohort retrograde study was carried out, for archival material teaching-scientific diagnostic laboratory Tbilisi State Medical University years 2019-2021 used. The results showed that molecular subtypes invasive carcinomas express CK20 CK5 with intensity. Moreover, there are mixed, hybrid forms coexistence both markers, indicates intratumoral heterogeneous nature carcinomas, probably depends clinical course prognosis tumors histological type. phenotypic characteristics low- high-grade papillary fundamentally from gives reason assume they require additional genomic changes transform into carcinoma.The differences between them likely determine risk transformation. CK20, CK5, apoptotic proliferative androgen receptor expression. Together, it can be used assess transformation noninvasive